I am not a virologist, but I am wondering if the 94%+ efficacy of Pfizer and Moderna could actually make them less effective against new variants. In statistics, it is well known that you can increase the statistical relevance of a model by adding more variables, but the more you add the less effective it becomes for forecasting. In statistics this is called overfitting.

So, beyond T-cells, I am wondering if it might be similar in situations like this - targeting too specifically on one virus could give great stats against that virus, but make it less generally effective.

Any virologists care to comment on this thought?